New bacterial tRNA species discovered may aid in antibiotic synthesis


chinese scientists discovered a new RNA species transfer (tRNA) bacterialwhich can aid in the synthesis of antibiotics, according to the Chinese Academy of Sciences (CAS).

A research team from the Northwest Institute of Eco-Environment and Resources (NIEER), under the CAS umbrella, discovered the tRNA-Asp-AUC of a streptomycete from the fast-growing desert, decoding the GAU codons and finding their functional characterization.

“The study provides an effective strategy to increase antibiotic production and expand the repertoire of much-needed new bioactive metabolites produced by these valuable bacteria,” said Liu Guangxiu, a NIEER researcher and leader of the study.

Soil microorganisms can produce various secondary metabolites, which have a great potential to produce the antibiotic synthesis.

Bacterial tRNA could help medicine, veterinary and food production

doWhat is streptomycete where was tRNA discovered? Streptomycete is a kind of microorganism that can produce various kinds of secondary metabolites of value in clinical treatment, animal husbandry, and the production of insect-resistant crops.

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“The results of the new study establish a new inefficient wobble base pairing paradigm involving GAU codons as an evolved strategy for regulating gene expression and, in particular, antibiotic biosynthesis,” Liu said.

The results of the study were published in the journal Nucleic Acids Research.

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